Just a thought, related to no single comment above:
Restaurants, like people, have a life cycle. This is natural.
Bob was a great guy, until he failed to live. Now he is a loser.
I think we need to be careful considering the failure to exist forever as a "failure." Many businesses run their course. Sometimes the decision to close a business is the decision NOT to "fail."
For example, Frank Unkle's had a great run. The family dynamic changed drastically. And then of course, Tracy and Carol influenced Charcoal House into the 90s. The Sabas and Szumigalas operate successful businesses today. I believe Frank's great grandson manages Bar145. It's in the blood.
Later, If I recall correctly, Jim Avolt and/or some investors did a ton of work on that building and ran a busy food/bar/event/weekend band business for a while. We don't know which decisions were forced, and which were choices. I wouldn't call Jim a failure.
Sometimes people don't choose to stay on a rollercoaster forever.
Just because the current owner lets it languish doesn't mean prior owners all "failed."
Jim Z. and Eric H. kicked serious ass in 329 N. Huron, most notably, spinning off a monster chef for the Art Museum, and now a local favorite, Registry Bistro. It also spun off another chef, who was at the Zoo and now the head chef for Health Care Reit. This was all before the food renaissance in Toledo. The business outlasted the Hillenbrand Zaleski partnership, and despite competing properties (Like the Secor Building Project and 20 North Gallery) these guys hung tough and provided a really, really excellent experience. While everyone else was fleeing, they created a destination. I blame competing expenses, a dissolved partnership, and the biggest recession in many years for their "failure." But thank God they came along and succeeded for a time. I'd finance Jim Zaleski's next creative idea in a minute. The owners of Martini and Nuzzi? I see their vision as black painted walls and beer bucket specials. Maybe a crap sandwich from a poorly performing health department kitchen.
I think the cursed spaces are fewer than the examples of incompetent owners underestimating the business.
If SOMEBODY had a good run there, it may not be the space.
That leaves the strip club/restaurant/brewery/laser hair removal place squarely on the list.